Twisted, twisted sisters! Emma came to Adrienne for help because the Massachusetts Academy was having financial trouble during the Generation X run. Adrienne accepted the offer in place for her to be the new headmistress. Later, she planted bombs at the Massachusetts Academy and killed Synch in the process, so Emma killed her with a gun since they were immune to their powers. Emma had hauntings of Adrienne and the death of the student, but later admitted she didn't regret it and wished she had killed her sister sooner.
In the Emma Frost series, Adrienne was antagonistic to her sister and shocked that father Frost selected Emma as the heir to his inheritance.